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From the Biological Effect to Regulation: How can New Approaches in Substance Evaluation Help?

On 11 and 12 March 2019, a workshop on the risk assessment of substances in the aquatic environment will take place at the University of Tübingen.
Juvenile Bachforelle

In the risk assessment of substances for the aquatic environment, efficacy tests are currently investigating apical parameters such as mortality, immobilization of organisms or their growth and reproduction after relatively short-term exposure to single substances. Specific as well as direct and indirect effects of chronic stress remain largely or totally unconsidered. These can influence the resilience of organisms and only have a long-term impact on populations. Also neglected are topics such as mixture toxicity, pulse load or effects of transformation products as well as formulations.

Whether and to what extent such long-term subtle effects influence the worldwide decline of species in aquatic (and terrestrial) ecosystems is poorly known. Within the framework of the workshop, current results on these topics will be presented and ways to integrate them into the process of substance approval will be discussed. Furthermore, the suitability of in vitro systems for the detection of organismic effects will be discussed. Special attention will be given to the concept of Adverse Outcome Pathways (AOP) as it has already found its way into substance regulation in the US. In this workshop, scientists want to discuss with regional, national and international authorities which data in Germany or the EU should be considered. In addition, the topic area will be considered in the context of legal and ethical obligation for the preventive protection of humans and the environment.

The workshop will be organized by the team of the project Effect-Net at the University of Tübingen. If you have any questions about content, please refer to Prof. Rita Triebskorn (University of Tübingen).




Participation in the workshop is free of charge. If you are interested in attending the event, please register by email or fax using the registration form (see contact below) by 25 February 2019 at the latest.



Coordination Office Water Research Network Baden-Württemberg

Karlsruhe Institute of Technology (KIT)

Email: info∂wassernetzwerk-bw.de

Fax: +49 721 608-46497